Drug Information

Drug General Information
Drug ID
D0M0UU
Former ID
DIB001415
Drug Name
ZYGK-1
Synonyms
Glucokinase activator (oral, diabetes), Zydus-Cadila
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Phase 1 [523690]
Company
Zydus-Cadila Group
Target and Pathway
Target(s) Glucokinase Target Info Activator [543714]
KEGG Pathway Glycolysis / Gluconeogenesis
Galactose metabolism
Starch and sucrose metabolism
Amino sugar and nucleotide sugar metabolism
Butirosin and neomycin biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
Insulin signaling pathway
Insulin secretion
Prolactin signaling pathway
Glucagon signaling pathway
Type II diabetes mellitus
Maturity onset diabetes of the young
Central carbon metabolism in cancer
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor network
PathWhiz Pathway Nucleotide Sugars Metabolism
Starch and Sucrose Metabolism
Galactose Metabolism
Trehalose Degradation
Reactome Regulation of gene expression in beta cells
Glucose transport
Glycolysis
WikiPathways SIDS Susceptibility Pathways
Glycolysis and Gluconeogenesis
MAPK Signaling Pathway
Regulation of beta-cell development
Metabolism of carbohydrates
Hexose transport
References
Ref 523690ClinicalTrials.gov (NCT01472809) A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of Oral ZYGK1 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 543714(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2798).

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