Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M0UU
|
||||
| Former ID |
DIB001415
|
||||
| Drug Name |
ZYGK-1
|
||||
| Synonyms |
Glucokinase activator (oral, diabetes), Zydus-Cadila
|
||||
| Indication | Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] | Phase 1 | [1] | ||
| Company |
Zydus-Cadila Group
|
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| Target and Pathway | |||||
| Target(s) | Glucokinase | Target Info | Activator | [2] | |
| KEGG Pathway | Glycolysis / Gluconeogenesis | ||||
| Galactose metabolism | |||||
| Starch and sucrose metabolism | |||||
| Amino sugar and nucleotide sugar metabolism | |||||
| Butirosin and neomycin biosynthesis | |||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| Carbon metabolism | |||||
| Insulin signaling pathway | |||||
| Insulin secretion | |||||
| Prolactin signaling pathway | |||||
| Glucagon signaling pathway | |||||
| Type II diabetes mellitus | |||||
| Maturity onset diabetes of the young | |||||
| Central carbon metabolism in cancer | |||||
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | ||||
| HIF-1-alpha transcription factor network | |||||
| PathWhiz Pathway | Nucleotide Sugars Metabolism | ||||
| Starch and Sucrose Metabolism | |||||
| Galactose Metabolism | |||||
| Trehalose Degradation | |||||
| Reactome | Regulation of gene expression in beta cells | ||||
| Glucose transport | |||||
| Glycolysis | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Glycolysis and Gluconeogenesis | |||||
| MAPK Signaling Pathway | |||||
| Regulation of beta-cell development | |||||
| Metabolism of carbohydrates | |||||
| Hexose transport | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01472809) A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of Oral ZYGK1 in Healthy Volunteers. U.S. National Institutes of Health. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2798). | ||||
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