| Drug General Information |
| Drug ID |
D0U2FN
|
| Former ID |
DIB009123
|
| Drug Name |
Romazarit
|
| Synonyms |
ORE-5007; Metabolic modulator (obesity/hyperlipidemia), Ore Pharmaceuticals
|
| Drug Type |
Small molecular drug
|
| Indication |
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]
|
Preclinical |
[1]
|
|---|
| Company |
Roche Holding AG
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H16ClNO4
|
| Canonical SMILES |
C(C(=O)O)(OCc1c(nc(o1)c1ccc(cc1)Cl)C)(C)C
|
| CAS Number |
CAS 109543-76-2
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Peroxisome proliferator activated receptor alpha |
Target Info |
Modulator |
[2]
|
|---|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
cAMP signaling pathway
|
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Adipocytokine signaling pathway
|
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Glucagon signaling pathway
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Hepatitis C
|
|
Pathway Interaction Database
|
RXR and RAR heterodimerization with other nuclear receptor
|
|
Reactome
|
RORA activates gene expression
|
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BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
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PPARA activates gene expression
|
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YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
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Transcriptional activation of mitochondrial biogenesis
|
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Activation of gene expression by SREBF (SREBP)
|
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Transcriptional regulation of white adipocyte differentiation
|
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Nuclear Receptor transcription pathway
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Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
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Circadian Clock
|
|
WikiPathways
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Nuclear Receptors in Lipid Metabolism and Toxicity
|
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Nuclear Receptors Meta-Pathway
|
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Estrogen Receptor Pathway
|
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PPAR Alpha Pathway
|
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Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
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Transcriptional Regulation of White Adipocyte Differentiation
|
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YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
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Activation of Gene Expression by SREBP (SREBF)
|
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Adipogenesis
|
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SREBF and miR33 in cholesterol and lipid homeostasis
|
|
Circadian Clock
|
|
Nuclear Receptors
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000969) |
|---|
| REF 2 | Fibrates as therapy for osteoarthritis and rheumatoid arthritis? A systematic review. Ther Adv Musculoskelet Dis. 2013 February; 5(1): 33-44. |
|---|
