Drug Information

Drug General Information
Drug ID
D02CRG
Former ID
DNC001150
Drug Name
Premarin
Drug Type
Small molecular drug
Indication Menopause [ICD9: 627.2; ICD10:N95.0] Approved [523937]
Structure
Download
2D MOL

3D MOL
Formula
C18H22NaO5S+
Canonical SMILES
CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.[Na+]
InChI
1S/C18H22O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/t14-,15-,16+,18+;/m1./s1
InChIKey
VUCAHVBMSFIGAI-ZFINNJDLSA-N
CAS Number
CAS 12126-59-9
PubChem Compound ID
5351489
PubChem Substance ID
541403, 8138021, 57361384, 80236169, 113904620, 126677587
ChEBI ID
ChEBI:8389
Target and Pathway
Target(s) Estrogen receptor beta Target Info Antagonist [535660], [536952]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
References
Ref 523937ClinicalTrials.gov (NCT01613170) Premarin Versus Toviaz for Treatment of Overactive Bladder. U.S. National Institutes of Health.
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 536952Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination. Mol Endocrinol. 2009 Jan;23(1):74-85. Epub 2008 Nov 26.

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