Target Validation Information
Target ID T11288
Target Name Multidrug resistance-associated protein 1
Target Type
Successful
Drug Potency against Target Sulfinpyrazone Drug Info IC50 = 420 uM [552346]
XR-9577 Drug Info IC50 = 320 nM [529220]
XR-9504 Drug Info IC50 = 260 nM [529220]
XR-9544 Drug Info IC50 = 50 nM [529220]
L-660771 Drug Info IC50 = 7570 nM [529644]
XR-9456 Drug Info IC50 = 300 nM [529220]
References
Ref 552346Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103.
Ref 529220Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
Ref 529220Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
Ref 529220Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
Ref 529644Bioorg Med Chem Lett. 2008 Sep 1;18(17):4761-3. Epub 2008 Aug 3.A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.
Ref 529220Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. Epub 2007 Nov 28.Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.

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