| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T84040 | ||||
| Target Name | Transient receptor potential cation channel subfamily A member 1 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | 2-methyl-1-(pyridin-3-yl)pent-1-en-3-one oxime | Drug Info | IC50 = 17000 nM | ||
| 2-methyl-1-(pyridin-4-yl)pent-1-en-3-one oxime | Drug Info | IC50 = 8610 nM | |||
| 2-methyl-1-(thiophen-2-yl)pent-1-en-3-one oxime | Drug Info | IC50 = 11000 nM | |||
| 2-methyl-1-(thiophen-3-yl)pent-1-en-3-one oxime | Drug Info | IC50 = 1320 nM | |||
| AMG-9090 | Drug Info | IC50 = 7 nM | |||
| AMG-2504 | Drug Info | IC50 = 105 nM | |||
| AMG-7160 | Drug Info | IC50 = 28 nM | |||
| AP18 5 | Drug Info | IC50 = 4500 nM | |||
| AMG-5445 | Drug Info | IC50 = 29 nM | |||
| 3-Methyl-4-phenylbut-3-en-2-one oxime | Drug Info | IC50 = 2700 nM | [530546] | ||
| References | |||||
| Ref 530546 | Bioorg Med Chem Lett. 2010 Jan 1;20(1):276-9. Epub 2009 Oct 30.Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor. | ||||
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