Target Validation Information
Target ID T11822
Target Name Retinoic acid receptor
Target Type
Successful
Drug Potency against Target Vitamin A Drug Info IC50 = 5 nM [553252]
Action against Disease Model Isotretinoin EC50 on differentiating N1E-115 cells: 16000nM [552841] Drug Info
Adapalene Normal h uMan keratinocytes transglutaminase 1 expression IC50: 2.5 nM [553294] Drug Info
References
Ref 553252Didehydroretinoic acid: retinoid receptor-mediated transcriptional activation and binding properties. Biochem Pharmacol. 1997 Apr 4;53(7):1049-53.
Ref 552841Effect of culture age on the susceptibility of differentiating neuroblastoma cells to retinoid cytotoxicity. Biotechnol Bioeng. 1996 Jun 5;50(5):580-6.
Ref 553294Pharmacology of adapalene. Br J Dermatol. 1998 Oct;139 Suppl 52:3-7.

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