Target General Information
Target ID	T00494
Target Name	ATP-binding cassette transporter 1
Synonyms	ABC-1; ATP-binding cassette 1; ATP-binding cassette transporter (ABCA1) transmembrane protein; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; Cholesterol efflux regulatory protein; Cholesterol mobilizing transporter ABCA1; ABCA1
Target Type	Successful
Gene Name	ABCA1
Biochemical Class	ABC transporter
UniProt ID	ABCA1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Coronary artery disease
Example drug	Probucol			Approved	[538489], [542297], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.10 Z-score: -0.33 P-value: 4.88E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 538489	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017535.
Ref 542297	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7277).
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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