Target General Information
Target ID	T01575
Target Name	Sphingosine 1 phosphate lyase 1
Synonyms	S1PL; SP-lyase 1; SPL 1; Sphingosine-1-phosphate aldolase; hSPL; SGPL1
Target Type	Clinical Trial
Gene Name	SGPL1 {ECO:0000312|HGNC:HGNC:10817}||Synonyms=KIAA1252 {ECO:0000303|PubMed:10574462}
Biochemical Class	Carbon-carbon lyase
UniProt ID	SGPL1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Rheumatoid arthritis
Example drug	LX2931			Phase 2	[522666], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.38 Z-score: 0.90 P-value: 1.63E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 522666	ClinicalTrials.gov (NCT00903383) Study of LX3305 in Subjects With Active Rheumatoid Arthritis on Stable Methotrexate. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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