Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T02318 | ||||
| Target Name | B-cell-activating factor | ||||
| Synonyms | B cell-activating factor; B lymphocyte stimulator; BAFF; BLyS; Dendritic cell-derived TNF-like molecule; TALL-1; TNF-and APOL-related leukocyte expressed ligand 1; UNQ401/PRO738; TNFSF13B | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | TNFSF13B | ||||
| Biochemical Class | Cytokine: tumor necrosis factor | ||||
| UniProt ID | TN13B_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Myeloma | ||||
| Example drug | Tabalumab | Phase 3 | [532166], [542916], [1572592] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.04 Z-score: 0.09 P-value: 4.51E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Multiple sclerosis | ||||
| Tissue | Spinal cord | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.53 Z-score: 0.43 P-value: 5.73E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Disease | Rheumatoid arthritis | ||||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.10 Z-score: 0.10 P-value: 4.50E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Reference | |||||
| Ref 542916 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8000). | ||||
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