Target General Information
Target ID	T02562
Target Name	Prostaglandin E synthase
Synonyms	MGST1-L1; MPGES-1; Microsomal glutathione S-transferase 1-like 1; Microsomal prostaglandin E synthase 1; P53-induced apoptosis protein 12; PGE synthase; PTGES
Target Type	Clinical Trial
Gene Name	PTGES
Biochemical Class	Intramolecular oxidoreductases
UniProt ID	PTGES_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Alzheimer's disease
Example drug	AAD-2004			Phase 1	[531887], [1572592]
Tissue	Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.05 Z-score: -0.24 P-value: 7.92E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 531887	Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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