Target General Information
Target ID T02677
Target Name Apoptosis inhibitor survivin
Synonyms Apoptosis inhibitor 4; Apoptosis inhibitor survivin; Survivin; BIRC5
Target Type Clinical Trial
Gene Name BIRC5
Biochemical Class Inhibitor of apoptosis
UniProt ID BIRC5_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Lung cancer
Example drug CV-9201 Phase 1/2 [1], [2]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 1.63
Z-score: 5.29
P-value: 1.67E-190
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 1.69
Z-score: 5.07
P-value: 1.67E-135
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Disease Ovarian cancer
Example drug DPX-Survivac Phase 1/2 [3], [2]
Tissue Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 1.62
Z-score: 2.68
P-value: 6.97E-05
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 1.16
Z-score: 0.70
P-value: 9.19E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
REF 1ClinicalTrials.gov (NCT00923312) Trial of an RNActive-Derived Cancer Vaccine in Stage IIIB/IV Non Small Cell Lung Cancer (NSCLC). U.S. National Institutes of Health.
REF 2NCBI GEO: archive for functional genomics data sets--update.
REF 32011 Pipeline of Immunovaccine.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.