Target General Information
Target ID	T03346
Target Name	Interleukin-4 receptor alpha
Synonyms	CD124 antigen; IL-4R; IL-4R-alpha; IL4R
Target Type	Successful
Gene Name	IL4R
Biochemical Class	Cytokine receptor
UniProt ID	IL4RA_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Atopic dermatitis
Example drug	Dupilumab			Approved	[889446], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.76 Z-score: 3.74 P-value: 1.48E-08
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Asthma
Example drug	SAR231893			Phase 3	[524747], [1572592]
Tissue	Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.16 Z-score: 0.37 P-value: 1.02E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Idiopathic pulmonary fibrosis
Example drug	SAR-156597			Phase 2	[549242], [1572592]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.59 Z-score: -1.29 P-value: 6.07E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 549242	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034106)
Ref 524747	ClinicalTrials.gov (NCT02134028) Long-Term Safety Evaluation of Dupilumab in Patients With Asthma. U.S. National Institutes of Health.
Ref 889446	Drugs@FDA (Edaravone)
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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