Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T03644 | ||||
| Target Name | Alpha-synuclein | ||||
| Synonyms | NACP; NonA beta component of AD amyloid; NonA4 component of amyloid precursor; SNCA | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | SNCA | ||||
| Biochemical Class | Synuclein family | ||||
| UniProt ID | SYUA_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Alzheimer's disease | ||||
| Example drug | Posiphen R-phenserine | Phase 1 | [1], [2] | ||
| Tissue | Entorhinal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.64 Z-score: -0.92 P-value: 7.86E-08 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Parkinson's disease | ||||
| Example drug | RG7935 | Phase 1 | [3], [2] | ||
| Tissue | Substantia nigra tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.26 Z-score: -0.33 P-value: 1.04E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5??ntranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression. Parkinson's Disease Volume 2012 (2012), Article ID 142372, Page(13). | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040327) | ||||
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