Target General Information
Target ID T03755
Target Name Apoptosis regulator Bcl-W
Synonyms Apoptosis regulator Bcl-W; Bcl2-L-2; BCL2L2
Target Type Clinical Trial
Gene Name BCL2L2
Biochemical Class Bcl-2 family
UniProt ID B2CL2_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Lung cancer
Example drug ABT-263 Phase 2 [543070], [551607], [1572592]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.69
Z-score: -1.67
P-value: 1.83E-48
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.70
Z-score: -1.56
P-value: 1.19E-28
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 543070(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8319).
Ref 551607Clinical pipeline report, company report or official report of Roche (2009).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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