Target General Information
Target ID	T05114
Target Name	Chymase
Synonyms	Mast cell protease I; CMA1
Target Type	Clinical Trial
Gene Name	CMA1
Biochemical Class	Peptidase
UniProt ID	CMA1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Asthma
Example drug	JNJ-10311795			Phase 2	[541688], [1572592]
Tissue	Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.08 Z-score: -0.17 P-value: 2.97E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Atopic dermatitis
Example drug	ASB17061			Phase 2	[524171], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.92 Z-score: -1.08 P-value: 1.20E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	JNJ-10311795			Phase 2	[541688], [1572592]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.09 Z-score: -0.12 P-value: 3.49E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	JNJ-10311795			Phase 2	[541688], [1572592]
Tissue	Small airway epithelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.07 Z-score: 0.40 P-value: 2.27E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Myeloma
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.62 Z-score: -3.21 P-value: 3.36E-05
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 541688	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6563).
Ref 524171	ClinicalTrials.gov (NCT01756898) A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of ASB17061 Capsules in Adult Subjects With Atopic Dermatitis. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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