Target General Information
Target ID	T05351
Target Name	Myristoylated alanine-rich C-kinase substrate
Synonyms	80KL protein; Myristoylated alaninerich Ckinase substrate; PKCSL; Protein kinase C substrate, 80 kDa protein, light chain; MARCKS
Target Type	Clinical Trial
Gene Name	MARCKS
Biochemical Class	Myristoylated alanine-rich C-kinase substrate
UniProt ID	MARCS_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Chronic obstructive pulmonary disease
Example drug	BIO-11006			Phase 2	[1], [2]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.15 Z-score: -0.28 P-value: 1.55E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	BIO-11006			Phase 2	[1], [2]
Tissue	Small airway epithelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.18 Z-score: -0.50 P-value: 8.74E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
REF 1	ClinicalTrials.gov (NCT00648245) Effectiveness and Safety of BIO-11006 Inhalation Solution to Treat the Overproduction of Mucus and Inflammation in COPD. U.S. National Institutes of Health.
REF 2	NCBI GEO: archive for functional genomics data sets--update.

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