Target expression details

Target General Information
Target ID T05849
Target Name Gastrin/cholecystokinin type B receptor
Synonyms CCK-B receptor; CCK-BR; CCKBR
Target Type Successful
Gene Name CCKBR
Biochemical Class GPCR rhodopsin
UniProt ID GASR_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Ulcerative colitis
Example drug GASTRAZOLE Phase 3 [528144], [1572592]
Tissue Colon mucosal tissue
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.12
Z-score: 0.22
P-value: 3.15E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of the persons with other diseases not directly affecting the tissue
Download target gene expression data in the tissue of healthy individual
Disease Eosinophilic gastritis
Example drug Spiroglumide Phase 2 [551837], [1572592]
Tissue Gastric antrum tissue
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.34
Z-score: 1.40
P-value: 7.65E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Disease Thyroid cancer
Example drug Demogastrin Phase 1 [549943], [1572592]
Tissue Thyroid
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 1.00E-03
Z-score: 4.05E-03
P-value: 6.53E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.07
Z-score: -0.33
P-value: 1.38E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 54994399mTc-Demogastrin 2 for CCK 2-receptor scintigraphy in medullary thyroid carcinoma. J Nucl Med. 2008; 49 (Supplement 1):115P.
Ref 528144Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 Apr 24;94(8):1107-15.
Ref 551837Progress medicinal chem PMC37H. Page(48).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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