Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T07663 | ||||
| Target Name | cGMP-binding cGMP-specific phosphodiesterase | ||||
| Synonyms | CGB-PDE; CGMP-binding cGMP-specific phosphodiesterase; Phosphodiesterase 5; PDE5A | ||||
| Target Type | Successful | ||||
| Gene Name | PDE5A | ||||
| Biochemical Class | Phosphoric diester hydrolases | ||||
| UniProt ID | PDE5A_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Rectal cancer | ||||
| Example drug | EXISULIND | Phase 3 | [521600], [1572592] | ||
| Tissue | Rectal colon tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.25 Z-score: -0.99 P-value: 1.60E-01 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.72 Z-score: -2.13 P-value: 4.01E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Asthma | ||||
| Example drug | SKF-96231 | Terminated | [545385], [1572592] | ||
| Tissue | Nasal and bronchial airway | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.07 Z-score: -0.17 P-value: 3.24E-05 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Breast cancer | ||||
| Tissue | Breast tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.28 Z-score: -0.69 P-value: 9.41E-20 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.20 Z-score: -0.68 P-value: 8.52E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 545385 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003084) | ||||
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