Target General Information
Target ID	T09507
Target Name	mRNA of ApoB-100
Synonyms	APOB (mRNA); Apo B100 (mRNA); Apo B48 (mRNA); Apolipoprotein B100 (mRNA); Apolipoprotein B48 (mRNA); APOB
Target Type	Successful
Gene Name	APOB
Biochemical Class	Target of antisense drug
UniProt ID	APOB_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Familial hypercholesterolemia
Example drug	Mipomersen			Approved	[1], [2], [3], [4]
Tissue	Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.03 Z-score: 0.18 P-value: 9.53E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
REF 1	Apolipoprotein B antisense inhibition--update on mipomersen. Curr Pharm Des. 2013;19(17):3132-42.
REF 2	2013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.
REF 3	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7364).
REF 4	NCBI GEO: archive for functional genomics data sets--update.

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