Target General Information
Target ID	T10482
Target Name	mRNA of factor XII
Synonyms	Coagulation factor XII (mRNA); Coagulation factor XIIa light chain (mRNA); F12 (mRNA); HAF (mRNA); Hageman factor (mRNA); F12
Target Type	Clinical Trial
Gene Name	F12
Biochemical Class	Peptidase
UniProt ID	FA12_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Alzheimer's disease
Example drug	methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate			Clinical trial	[541677], [1572592]
Tissue	Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.34 Z-score: -0.63 P-value: 1.43E-07
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 541677	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6553).
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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