Target General Information
Target ID	T10877
Target Name	ADP ribosyl cyclase 1
Synonyms	ADPribosyl cyclase 1; Cyclic ADPribose hydrolase 1; T10; cADPr hydrolase 1; CD38
Target Type	Clinical Trial
Gene Name	CD38
Biochemical Class	Glycosylases
UniProt ID	CD38_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Myeloma
Example drug	Daratumumab			Phase 3	[524935], [542416], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.22 Z-score: 0.69 P-value: 8.33E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 542416	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7395).
Ref 524935	ClinicalTrials.gov (NCT02252172) Study Comparing Daratumumab, Lenalidomide, and Dexamethasone With Lenalidomide and Dexamethasone in Participants With Previously Untreated Multiple Myeloma. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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