Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T12475 | ||||
| Target Name | Gonadotropin-releasing hormone receptor | ||||
| Synonyms | GnRH receptor; GnRH-R; Gonadotrophin releasing hormone receptor; Hypothalamic gonadotropin-releasing hormone receptor; GNRHR | ||||
| Target Type | Successful | ||||
| Gene Name | GNRHR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | GNRHR_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Endometriosis | ||||
| Example drug | Nafarelin | Approved | [536361], [540540], [1572592] | ||
| Tissue | Endometrium tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.02 Z-score: 0.09 P-value: 9.07E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Prostate cancer | ||||
| Example drug | Leuprorelin acetate | Approved | [550527], [1572592] | ||
| Tissue | Prostate | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.33E-02 Z-score: 0.04 P-value: 4.30E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Esophagal cancer | ||||
| Example drug | Ramorelix | Discontinued in Phase 1 | [546504], [1572592] | ||
| Tissue | Esophagus | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.10 Z-score: 1.49 P-value: 9.53E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 546504 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008630) | ||||
| Ref 540540 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3902). | ||||
| Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
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