Target General Information
Target ID	T14592
Target Name	Apoptosis mediating surface antigen FAS
Synonyms	Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; Tumor necrosis factor receptor superfamily member 6; FAS
Target Type	Clinical Trial
Gene Name	FAS
Biochemical Class	Cytokine receptor
UniProt ID	TNR6_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Glioma
Example drug	VB-111			Phase 2	[531640], [1572592]
Tissue	Brainstem tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.75 Z-score: 2.08 P-value: 1.66E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Glioma
Example drug	VB-111			Phase 2	[531640], [1572592]
Tissue	White matter
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.25 Z-score: -0.43 P-value: 4.18E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Rheumatoid arthritis
Example drug	DE-098			Phase 2	[547480], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.55 Z-score: 4.58 P-value: 9.19E-11
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Myeloma
Example drug	APO-010			Phase 1	[531313], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.69 Z-score: -2.65 P-value: 1.08E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 547480	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016731)
Ref 531313	APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo. Neuro Oncol. 2011 Feb;13(2):155-64.
Ref 531640	VB-111 for cancer. Expert Opin Biol Ther. 2011 Dec;11(12):1669-76.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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