Target General Information
Target ID T14676
Target Name A proliferation-inducing ligand
Synonyms A proliferation-inducing ligand; CD256; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TRDL-1; Tumor necrosis factor ligand superfamily member 13; TNFSF13
Target Type Clinical Trial
Gene Name TNFSF13
Biochemical Class Cytokine: tumor necrosis factor
UniProt ID TNF13_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Multiple sclerosis
Example drug Atacicept Phase 2 [530405], [537129], [1572592]
Tissue Spinal cord
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.13
Z-score: 0.79
P-value: 2.89E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Disease Rheumatoid arthritis
Example drug Atacicept Phase 2 [530405], [537129], [1572592]
Tissue Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.20
Z-score: -0.46
P-value: 3.53E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Reference
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 530405Atacicept: a new B lymphocyte-targeted therapy for multiple sclerosis. Nervenarzt. 2009 Dec;80(12):1462-72.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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