Target General Information
Target ID	T15344
Target Name	Activation-inducible TNFR family receptor
Synonyms	CD357; Glucocorticoid-induced TNFR-related protein; Tumor necrosis factor receptor superfamily member 18; TNFRSF18
Target Type	Clinical Trial
Gene Name	TNFRSF18
Biochemical Class	Cytokine receptor
UniProt ID	TNR18_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Melanoma
Example drug	TRX-518			Phase 1	[523249], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.54 Z-score: -0.70 P-value: 2.39E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Reference
Ref 523249	ClinicalTrials.gov (NCT01239134) Trial of TRX518 (Anti-GITR mAb) in Stage III or IV Malignant Melanoma or Other Solid Tumors. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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