Target General Information
Target ID	T16688
Target Name	Diglyceride acyltransferase
Synonyms	ACAT-related gene product 1; AGRP1; DGAT; Diacylglycerol O-acyltransferase 1; DGAT1
Target Type	Successful
Gene Name	DGAT1
Biochemical Class	Acyltransferase
UniProt ID	DGAT1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Type 2 diabetes
Example drug	PF-04620110			Terminated	[542774], [551489], [1572592]
Tissue	Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.41 Z-score: -0.62 P-value: 3.51E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Reference
Ref 542774	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7829).
Ref 551489	Clinical pipeline report, company report or official report of Pfizer (2011).
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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