Target General Information
Target ID T16739
Target Name Lysine specific histone demethylase 1
Synonyms BRAF35HDAC complex protein BHC110; Flavincontaining amine oxidase domaincontaining protein 2; Lysinespecific histone demethylase 1A; KDM1A
Target Type Clinical Trial
Gene Name KDM1A
Biochemical Class Flavin monoamine oxidase
UniProt ID KDM1A_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Lung cancer
Example drug GSK2879552 Phase 1 [524597], [1572592]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.51
Z-score: 1.91
P-value: 1.51E-76
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.46
Z-score: 1.66
P-value: 9.18E-44
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 524597ClinicalTrials.gov (NCT02034123) Investigation of GSK2879552 in Subjects With Relapsed/Refractory Small Cell Lung Carcinoma. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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