Target General Information
Target ID T20575
Target Name C-C chemokine receptor type 8
Synonyms C-C CKR-8; CC-CKR-8; CC-chemokine receptor CHEMR1; CCR-8; CKR-L1; CMKBRL2; Chemokine receptor CCR8; Chemokine receptor-like 1; GPR-CY6; GPRCY6; TER1; CCR8
Target Type Discontinued
Gene Name CCR8
Biochemical Class GPCR rhodopsin
UniProt ID CCR8_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Psoriasis
Example drug CCX-832 Discontinued in Phase 1 [548366], [1572592]
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.07
Z-score: 0.25
P-value: 2.96E-02
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.15
Z-score: 0.56
P-value: 1.10E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 548366Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025006)
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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