Target General Information
Target ID	T20808
Target Name	Isocitrate dehydrogenase
Synonyms	ICDM; IDH; IDP; Isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)specific ICDH; Oxalosuccinate decarboxylase; IDH2
Target Type	Clinical Trial
Gene Name	IDH2
Biochemical Class	Short-chain dehydrogenases reductases
UniProt ID	IDHP_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Acute myelocytic leukemia
Example drug	AG-221			Phase 1/2	[524966], [1572592]
Tissue	Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.11 Z-score: 0.24 P-value: 6.06E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 524966	ClinicalTrials.gov (NCT02273739) Study of Orally Administered AG-221 in Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation. U.S.National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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