Target expression details
Target General Information | |||||
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Target ID | T21334 | ||||
Target Name | Osteoclast differentiation factor | ||||
Synonyms | ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activatorof nuclear factor kappa B ligand; TNF-related activation-induced cytokine; TRANCE; TNFSF11 | ||||
Target Type | Successful | ||||
Gene Name | TNFSF11 | ||||
Biochemical Class | Cytokine: tumor necrosis factor | ||||
UniProt ID | TNF11_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Osteoporosis | ||||
Example drug | Denosumab | Approved | [1], [2], [3] | ||
Tissue | Bone marrow | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.16 Z-score: -0.37 P-value: 6.42E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Rheumatoid arthritis | ||||
Example drug | Denosumab | Phase 2 | [1], [2], [3] | ||
Tissue | Synovial tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.53 Z-score: 1.49 P-value: 1.51E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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Reference | |||||
REF 1 | Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. | ||||
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6886). | ||||
REF 3 | NCBI GEO: archive for functional genomics data sets--update. |
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