Target General Information
Target ID T22655
Target Name Mucosal addressin cell adhesion molecule 1
Synonyms MAdCAM-1; hMAdCAM-1; MADCAM1
Target Type Clinical Trial
Gene Name MADCAM1
UniProt ID MADCA_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Ulcerative colitis
Example drug PF-00547659 Phase 2 [536371], [1572592]
Tissue Colon mucosal tissue
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.34
Z-score: 0.54
P-value: 2.90E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 536371Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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