Target General Information
Target ID T22977
Target Name Superoxide dismutase [Cu-Zn]
Synonyms Superoxide dismutase; SOD1
Target Type Clinical Trial
Gene Name SOD1
Biochemical Class Oxidoreductases acting on superoxide as acceptor
UniProt ID SODC_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Atopic dermatitis
Example drug APN-201 Phase 1/2 [523766], [1572592]
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.12
Z-score: -1.01
P-value: 9.27E-05
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Multiple sclerosis
Tissue Spinal cord
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.25
Z-score: -0.58
P-value: 8.79E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref
Ref 523766ClinicalTrials.gov (NCT01513278) Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer. U.S. NationalInstitutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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