Target expression details

Target General Information
Target ID T25258
Target Name Multidrug resistance protein 1
Synonyms CD243 antigen; P-glycoprotein 1; ABCB1
Target Type Successful
Gene Name ABCB1
Biochemical Class Acid anhydrides hydrolase
UniProt ID MDR1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Ovarian cancer
Example drug Biricodar Approved [536248], [1572592]
Tissue Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.69
Z-score: -2.04
P-value: 1.53E-04
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.63
Z-score: -0.52
P-value: 3.32E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data in the tissue of healthy individual
Disease Lung cancer
Example drug CBT-1 Phase 3 [521968], [1572592]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.83
Z-score: -1.04
P-value: 3.12E-33
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.99
Z-score: -1.11
P-value: 1.12E-24
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 536248Pharmacological strategies for overcoming multidrug resistance. Curr Drug Targets. 2006 Jul;7(7):861-79.
Ref 521968ClinicalTrials.gov (NCT00437749) A Study of CBT-1 and Paclitaxel With Carboplatin in Patients With Advanced Inoperable Non-small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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