Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T25258 | ||||
| Target Name | Multidrug resistance protein 1 | ||||
| Synonyms | CD243 antigen; P-glycoprotein 1; ABCB1 | ||||
| Target Type | Successful | ||||
| Gene Name | ABCB1 | ||||
| Biochemical Class | Acid anhydrides hydrolase | ||||
| UniProt ID | MDR1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Ovarian cancer | ||||
| Example drug | Biricodar | Approved | [1], [2] | ||
| Tissue | Ovarian tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.69 Z-score: -2.04 P-value: 1.53E-04 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.63 Z-score: -0.52 P-value: 3.32E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Lung cancer | ||||
| Example drug | CBT-1 | Phase 3 | [3], [2] | ||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.83 Z-score: -1.04 P-value: 3.12E-33 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.99 Z-score: -1.11 P-value: 1.12E-24 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | Pharmacological strategies for overcoming multidrug resistance. Curr Drug Targets. 2006 Jul;7(7):861-79. | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 3 | ClinicalTrials.gov (NCT00437749) A Study of CBT-1 and Paclitaxel With Carboplatin in Patients With Advanced Inoperable Non-small Cell Lung Cancer. U.S. National Institutes of Health. | ||||
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