Target General Information
Target ID	T25317
Target Name	Cholestenol delta-isomerase
Synonyms	3betahydroxysteroidDelta(8),Delta(7)isomerase; D8D7 sterol isomerase; Delta(8)Delta(7) sterol isomerase; Emopamilbinding protein; EBP
Target Type	Clinical Trial
Gene Name	EBP
Biochemical Class	Intramolecular oxidoreductases
UniProt ID	EBP_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Rheumatoid arthritis
Example drug	SR-31747			Phase 2	[534643], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.25 Z-score: 0.89 P-value: 3.15E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 534643	Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther. 1998 Jun;285(3):1296-302.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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