Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T25608 | ||||
| Target Name | Free fatty acid receptor 1 | ||||
| Synonyms | Free fatty acid receptor 1; Gprotein coupled receptor 40; FFAR1 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | FFAR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | FFAR1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Type 2 diabetes | ||||
| Example drug | TAK-875 | Phase 3 | [1], [2], [3] | ||
| Tissue | Liver tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.08 Z-score: -1.33 P-value: 6.14E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Reference | |||||
| REF 1 | ClinicalTrials.gov (NCT01609582) Study of TAK-875 in Adults With Type 2 Diabetes and Cardiovascular Disease or Risk Factors for Cardiovascular Disease. U.S. National Institutes of Health. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6484). | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
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