Target General Information
Target ID T25739
Target Name Zinc transporter ZIP6
Synonyms Estrogen-regulated protein LIV-1; Solute carrier family 39 member 6; ZIP-6; Zrt- and Irt-like protein 6; SLC39A6
Target Type Clinical Trial
Gene Name SLC39A6
Biochemical Class Zinc (zn(2+))-iron (fe(2+)) permease
UniProt ID S39A6_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Breast cancer
Example drug SGN-LIV1A Phase 1 [524488], [1572592]
Tissue Breast tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.26
Z-score: 0.25
P-value: 3.54E-08
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.41
Z-score: 0.34
P-value: 4.69E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 524488ClinicalTrials.gov (NCT01969643) A Safety Study of SGN-LIV1A in Breast Cancer Patients. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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