Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T27137 | ||||
| Target Name | Metabotropic glutamate receptor 1 | ||||
| Synonyms | Glutamate receptor mGLU1; mGLUR1; GRM1 | ||||
| Target Type | Research | ||||
| Gene Name | GRM1 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | GRM1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Schizophrenia | ||||
| Example drug | AZD8529 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Superior temporal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.11 Z-score: 0.74 P-value: 2.46E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Schizophrenia | ||||
| Example drug | AZD8529 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Pre-frontal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.05 Z-score: -0.20 P-value: 2.31E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7678). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029661) | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
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