Target General Information
Target ID	T28226
Target Name	GTP cyclohydrolase-I
Synonyms	GTP-CH-I; Guanosine triphosphate cyclohydrolase I; GCH1
Target Type	Clinical Trial
Gene Name	GCH1
Biochemical Class	Carbon-nitrogen hydrolase
UniProt ID	GCH1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Parkinson's disease
Example drug	ProSavin			Phase 1/2	[524296], [1572592]
Tissue	Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -1.59 Z-score: -1.53 P-value: 3.38E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 524296	ClinicalTrials.gov (NCT01856439) Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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