Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T29879 | ||||
| Target Name | Integrin alpha-5 | ||||
| Synonyms | CD49e antigen; FNRA; Fibronectin receptor subunit alpha; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; VLA-5; ITGA5 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | ITGA5 | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | ITA5_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Asthma | ||||
| Example drug | TR-14531 | Discontinued in Phase 1 | [547054], [1572592] | ||
| Tissue | Nasal and bronchial airway | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.19 Z-score: 0.25 P-value: 2.32E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Multiple sclerosis | ||||
| Example drug | ZD-7349 | Discontinued in Phase 1 | [546708], [1572592] | ||
| Tissue | Spinal cord | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.07 Z-score: -0.59 P-value: 2.73E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 546708 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009742) | ||||
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