Target General Information
Target ID T31992
Target Name Carbonic anhydrase XIV
Synonyms CA-XIV; Carbonate dehydratase XIV; UNQ690/PRO1335; CA14
Target Type Successful
Gene Name CA14
Biochemical Class Carbon-oxygen lyases
UniProt ID CAH14_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Breast cancer
Example drug COUMATE Phase 2 [531371], [1572592]
Tissue Breast tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.09
Z-score: -0.16
P-value: 5.79E-07
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.13
Z-score: -0.35
P-value: 3.73E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 531371Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer. Expert Rev Anticancer Ther. 2011 Feb;11(2):179-83.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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