Target General Information
Target ID	T33901
Target Name	Niemann-Pick C1-like protein 1
Synonyms	Niemann-Pick C1 Like 1; NPC1L1
Target Type	Successful
Gene Name	NPC1L1
Biochemical Class	Resistance-nodulation-cell division
UniProt ID	NPCL1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Familial hypercholesterolemia
Example drug	Ezetimibe			Approved	[536740], [541898], [1572592]
Tissue	Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.05 Z-score: -0.27 P-value: 1.75E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 541898	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6816).
Ref 536740	Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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