Target expression details

Target General Information
Target ID T35734
Target Name Soluble epoxide hydrolase
Synonyms CEH; Cytosolic epoxide hydrolase; Epoxide Hydrolase; Epoxide hydratase; SEH; EPHX2
Target Type Clinical Trial
Gene Name EPHX2
Biochemical Class Etherhydrolase
UniProt ID HYES_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Chronic obstructive pulmonary disease
Example drug GSK2256294 Phase 1 [532153], [1572592]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.10
Z-score: -0.27
P-value: 8.78E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Disease Chronic obstructive pulmonary disease
Example drug GSK2256294 Phase 1 [532153], [1572592]
Tissue Small airway epithelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.18
Z-score: -0.42
P-value: 4.40E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 532153Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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