Target General Information
Target ID T40010
Target Name EGF-like domain-containing protein 7
Synonyms Multiple EGF-like domain protein 7; Multiple epidermal growth factor-like domain protein 7; NOTCH4-like protein; VE-statin; Vascular endothelial statin; ZNEU1; EGFL7
Target Type Clinical Trial
Gene Name EGFL7
Biochemical Class Growth factor
UniProt ID EGFL7_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Lung cancer
Example drug MEGF0444A Phase 2 [522678], [1572592]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -1.22
Z-score: -2.22
P-value: 6.32E-79
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -1.51
Z-score: -2.22
P-value: 1.26E-45
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Disease Rectal cancer
Example drug MEGF0444A Phase 2 [522678], [1572592]
Tissue Rectal colon tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.07
Z-score: 0.33
P-value: 2.56E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.04
Z-score: 0.39
P-value: 4.44E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 522678ClinicalTrials.gov (NCT00909740) A Study of the Safety and Pharmacokinetics of MEGF0444A Administered to Patients With Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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