Target General Information
Target ID T40800
Target Name Sodium/potassium-transporting ATPase alpha-1
Synonyms Na+/K+ ATPase 1; Sodium pump 1; Sodium/potassium-transporting ATPase alpha1; ATP1A1
Target Type Successful
Gene Name ATP1A1
Biochemical Class Acid anhydrides hydrolase
UniProt ID AT1A1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Chronic obstructive pulmonary disease
Example drug Almitrine Approved [534891], [1572592]
Tissue Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 1.00E-02
Z-score: 0.06
P-value: 4.66E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Chronic obstructive pulmonary disease
Example drug Almitrine Approved [534891], [1572592]
Tissue Small airway epithelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.03
Z-score: -0.19
P-value: 3.31E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 534891Improving oxygenation during bronchopulmonary lavage using nitric oxide inhalation and almitrine infusion. Anesth Analg. 1999 Aug;89(2):302-4.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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