Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T45262 | ||||
| Target Name | Corticotropin releasing factor receptor 1 | ||||
| Synonyms | CRF receptor; CRF-1 receptor; CRF-R; CRF-R1; CRF1; CRH-R 1; Corticotropin-releasing hormone receptor 1; Corticotropin-releasing hormone type 1 receptor; CRHR1 | ||||
| Target Type | Successful | ||||
| Gene Name | CRHR1 | ||||
| Biochemical Class | GPCR secretin | ||||
| UniProt ID | CRFR1_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Depression | ||||
| Example drug | GSK586529 | Phase 1 | [1], [2] | ||
| Tissue | Pre-frontal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.02 Z-score: -0.10 P-value: 7.70E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Irritable bowel syndrome | ||||
| Example drug | GW876008 | Discontinued in Phase 2 | [3], [2] | ||
| Tissue | Rectal colon tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.04 Z-score: 0.15 P-value: 8.26E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | ClinicalTrials.gov (NCT00703547) A First Time in Human Study of GSK586529 in Healthy Volunteers. U.S. National Institutes of Health. | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 3 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. | ||||
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