Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T46084 | ||||
| Target Name | TNF related apoptosis inducing ligand | ||||
| Synonyms | Apo-2 ligand; Apo-2L; CD253; Protein TRAIL; Tumor necrosis factor ligand superfamily member 10; TNFSF10 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | TNFSF10 | ||||
| Biochemical Class | Cytokine: tumor necrosis factor | ||||
| UniProt ID | TNF10_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Brain cancer | ||||
| Example drug | DA-3607 | Phase 1 | [548564], [1572592] | ||
| Tissue | Nervous tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.16 Z-score: -0.18 P-value: 4.40E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Prostate cancer | ||||
| Example drug | Ad5-TRAIL | Phase 1 | [551576], [1572592] | ||
| Tissue | Prostate | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.18 Z-score: 0.37 P-value: 9.66E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Rectal cancer | ||||
| Example drug | Dulanermin | Terminated | [550794], [1572592] | ||
| Tissue | Rectal colon tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -1.09 Z-score: -3.90 P-value: 1.16E-05 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -1.69 Z-score: -3.77 P-value: 1.57E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 548564 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026657) | ||||
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