Target General Information
Target ID T49072
Target Name Urotensin II receptor
Synonyms G protein coupled receptor 14; UR-II-R; Urotensin-II receptor GPR14; UTS2R
Target Type Clinical Trial
Gene Name UTS2R
Biochemical Class GPCR rhodopsin
UniProt ID UR2R_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Asthma
Example drug GlaxoSmithKline Phase 1 [1], [2], [3]
Tissue Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.25
Z-score: -0.57
P-value: 2.85E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Reference
REF 1ClinicalTrials.gov (NCT01424280) Single Dose Study of GSK1440115 in Patients With Asthma. U.S. National Institutes of Health.
REF 2(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2164).
REF 3NCBI GEO: archive for functional genomics data sets--update.

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