Target expression details

Target General Information
Target ID T49639
Target Name Heat shock protein 70
Synonyms Chaperone protein dnaK; HSP70; Heat shock 70 kDa protein; Molecular chaperone Hsp70; HSF1
Target Type Clinical Trial
Gene Name HSPA1A
Biochemical Class HSF family
UniProt ID HS71A_HUMAN||HS71B_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Acute myelocytic leukemia
Example drug AG-858 Phase 2 [521552], [1572592]
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.32
Z-score: 1.20
P-value: 1.03E-20
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Disease Gastric cancer
Example drug Minnelide Phase 1 [524410], [1572592]
Tissue Gastric tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -4.07E-03
Z-score: -0.01
P-value: 2.62E-01
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.41
Z-score: 1.20
P-value: 3.38E-05
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 521552ClinicalTrials.gov (NCT00058747) AG-858 in Patients Who Are Cytogenetically Positive After Treatment With Gleevec . U.S. National Institutes of Health.
Ref 524410ClinicalTrials.gov (NCT01927965) Study of Minnelide in Patients With Advanced GI Tumors. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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