Target General Information
Target ID	T50688
Target Name	Glycoprotein IIb/IIIa receptor
Synonyms	Alpha(IIb)beta(3) integrin receptor; Fibrinogen receptor; GPIIb-IIIa receptor; Glycoprotein GP IIb/IIIa; Glycoprotein IIb/IIIa; Gp IIb/IIIa; GpIIb/IIIa receptor; Integrin IIb beta3; Integrin IIbbeta3; Integrin alpha IIb beta 3; Integrin alphaIIbbeta3; Platelet GPIIb-IIIa; Platelet GPIIb/IIIa receptor; Platelet glycoprotein IIb/IIIa fibrinogen receptor complex; Platelet integrin IIbbeta3
Target Type	Successful
Gene Name	ITGA2B
UniProt ID	ITA2B_HUMAN||ITB3_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Coronary artery disease
Example drug	DMP-444			Phase 3	[531571], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.11 Z-score: -0.45 P-value: 7.83E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Arteriosclerosis
Example drug	Gantofiban			Discontinued in Phase 2	[546857], [1572592]
Tissue	Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.10 Z-score: 0.39 P-value: 8.97E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 546857	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010688)
Ref 531571	Evaluation of 99mTc-labeled cyclic RGD peptide with a PEG4 linker for thrombosis imaging: comparison with DMP444. Bioconjug Chem. 2011 Aug 17;22(8):1715-22.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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