Target expression details
Target General Information | |||||
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Target ID | T50688 | ||||
Target Name | Glycoprotein IIb/IIIa receptor | ||||
Synonyms | Alpha(IIb)beta(3) integrin receptor; Fibrinogen receptor; GPIIb-IIIa receptor; Glycoprotein GP IIb/IIIa; Glycoprotein IIb/IIIa; Gp IIb/IIIa; GpIIb/IIIa receptor; Integrin IIb beta3; Integrin IIbbeta3; Integrin alpha IIb beta 3; Integrin alphaIIbbeta3; Platelet GPIIb-IIIa; Platelet GPIIb/IIIa receptor; Platelet glycoprotein IIb/IIIa fibrinogen receptor complex; Platelet integrin IIbbeta3 | ||||
Target Type | Successful | ||||
Gene Name | ITGA2B | ||||
UniProt ID | ITA2B_HUMAN||ITB3_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Coronary artery disease | ||||
Example drug | DMP-444 | Phase 3 | [531571], [1572592] | ||
Tissue | Peripheral blood | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.11 Z-score: -0.45 P-value: 7.83E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Arteriosclerosis | ||||
Example drug | Gantofiban | Discontinued in Phase 2 | [546857], [1572592] | ||
Tissue | Peripheral blood | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.10 Z-score: 0.39 P-value: 8.97E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 546857 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010688) |
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