Target General Information
Target ID T50688
Target Name Glycoprotein IIb/IIIa receptor
Synonyms Alpha(IIb)beta(3) integrin receptor; Fibrinogen receptor; GPIIb-IIIa receptor; Glycoprotein GP IIb/IIIa; Glycoprotein IIb/IIIa; Gp IIb/IIIa; GpIIb/IIIa receptor; Integrin IIb beta3; Integrin IIbbeta3; Integrin alpha IIb beta 3; Integrin alphaIIbbeta3; Platelet GPIIb-IIIa; Platelet GPIIb/IIIa receptor; Platelet glycoprotein IIb/IIIa fibrinogen receptor complex; Platelet integrin IIbbeta3
Target Type Successful
Gene Name ITGA2B
UniProt ID ITA2B_HUMAN||ITB3_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Coronary artery disease
Example drug DMP-444 Phase 3 [531571], [1572592]
Tissue Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.11
Z-score: -0.45
P-value: 7.83E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Arteriosclerosis
Example drug Gantofiban Discontinued in Phase 2 [546857], [1572592]
Tissue Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.10
Z-score: 0.39
P-value: 8.97E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 546857Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010688)
Ref 531571Evaluation of 99mTc-labeled cyclic RGD peptide with a PEG4 linker for thrombosis imaging: comparison with DMP444. Bioconjug Chem. 2011 Aug 17;22(8):1715-22.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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