Target General Information
Target ID T50823
Target Name Semaphorin-4D
Synonyms BB18; CD100; GR3; SEMA4D
Target Type Clinical Trial
Gene Name SEMA4D
Biochemical Class Semaphorin
UniProt ID SEM4D_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Multiple sclerosis
Example drug VX-15 Phase 1 [524181], [1572592]
Tissue Spinal cord
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.78
Z-score: -1.04
P-value: 2.68E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 524181ClinicalTrials.gov (NCT01764737) Evaluation of Safety, Tolerability, and PK of VX15/2503 In Patients With MS. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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